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Study identifier: NCT04152499 Synced from ClinicalTrials.gov · August 03, 2026
● Active Not Recruiting

Phase I-II, FIH, TROP2 ADC, Advanced Unresectable/Metastatic Solid Tumors, Refractory to Standard Therapies (KL264-01)

Condition: Epithelial Ovarian Cancer · Gastric Adenocarcinoma · Gastroesophageal Junction Adenocarcinoma  ·  Sponsor: Klus Pharma Inc.

PhasePhase 1/Phase 2
Planned participants1410
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

A Phase I-II, First-in-Human Study of SKB264 (Sac-TMT; MK-2870) in Patients with Locally Advanced Unresectable/Metastatic Solid Tumors who are refractory to Available Standard Therapies. Patient must have historically documented, incurable, locally advanced or metastatic cancer that are refractory to standard therapies of one of the following types: 1. Triple negative breast cancer 2. Epithelial ovarian cancer 3. Non-small cell lung cancer 4. Gastric adenocarcinoma/Gastroesophageal junction adenocarcinoma 5. Small cell lung cancer 6. HR+/ HER2-breast cancer 7. Head and neck squamous cell carcinoma 8. Endometrial carcinoma 9. Urothelial carcinoma 10. Cervical cancer

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

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Locations (109)

Los Angeles Hematology Oncology Medical GroupGlendale, California, United States
University of California Los AngelesLos Angeles, California, United States
Florida Cancer Specialists and Research InstituteSarasota, Florida, United States
START MidWestGrand Rapids, Michigan, United States
The University of Oklahoma Health Sciences CenterOklahoma City, Oklahoma, United States
Oklahoma Cancer Specialists and Research Institute, LLCTulsa, Oklahoma, United States
Providence Cancer Institute, Franz ClinicPortland, Oregon, United States
Mary Crowley Cancer ResearchDallas, Texas, United States
MD Anderson Cancer CenterHouston, Texas, United States
Virginia Cancer SpecialistsFairfax, Virginia, United States
Princess Margaret Cancer CentreToronto, Ontario, Canada
Sunnybrook Research InstituteToronto, Ontario, Canada

+ 97 more locations — full list on the registry record.

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