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Study identifier: NCT04069312 Synced from ClinicalTrials.gov · August 05, 2026
● Completed

Roflumilast or Azithromycin to Prevent COPD Exacerbations Trial

Condition: Chronic Obstructive Pulmonary Disease Severe · Chronic Bronchitis  ·  Sponsor: Johns Hopkins University

PhasePhase 3
Planned participants1032
Who can joinAll sexes, 40 Years to no upper limit
Healthy volunteersNo

About this study

A multi-center, randomized, 72-month, parallel- group, non-inferiority, phase III study to compare the effectiveness of roflumilast (Daliresp, 500 mcg quaque die (QD) or alternate regimen) therapy versus azithromycin (250 mg QD, 500 mg QD three times per week, or alternate regimen) to prevent hospitalization or death in a patients at high risk for COPD exacerbations.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

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Locations (28)

University of AlabamaBirmingham, Alabama, United States
University of ArizonaTucson, Arizona, United States
University of California, Davis HealthSacramento, California, United States
NorthwesternChicago, Illinois, United States
University of Illinois ChicagoChicago, Illinois, United States
NorthShore HospitalGlenview, Illinois, United States
University of IowaIowa City, Iowa, United States
University of KansasKansas City, Kansas, United States
Ochsner Medical CenterNew Orleans, Louisiana, United States
Johns Hopkins UniversityBaltimore, Maryland, United States
Baystate HealthSpringfield, Massachusetts, United States
University of MichiganAnn Arbor, Michigan, United States

+ 16 more locations — full list on the registry record.

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