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Plasma Analysis for Response Assessment and to DIrect the manaGement of Metastatic Prostate Cancer
Condition: Metastatic Prostate Cancer · Sponsor: University College, London
About this study
This research study is looking into plasma tumour deoxyribonucleic acid (ptDNA), a substance that is shed by cancer cells and can be detected in blood samples. Analysing ptDNA may therefore be able to provide more information about the characteristics of prostate cancer. This study will involve taking additional blood samples during standard treatment. The samples will be analysed in laboratories for levels of Prostate Specific Antigen (PSA); which gives information on the activity of the cancer; ptDNA; circulating tumour cells (ones that are derived from the cancer) (CTCs) and cells that affect immune system. The PARADIGM study is not, therefore, testing a new drug. Instead, the study is investigating if a new blood test can provide information about which current treatments for prostate cancer will work best for future patients with this disease. In the future and PARADIGM's ultimate aim is to identify which of the current treatment options will work best for patients. The research may also identify new opportunities for the development of drugs potentially useful in treating prostate cancer.
This description comes directly from the study's public registry record.
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No contact information is available for this study as per the public registry record.
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Locations (16)
| Aberdeen Royal Infirmary | Aberdeen, United Kingdom | — |
| Royal Bournemouth Hospital | Bournemouth, United Kingdom | — |
| Velindre University NHS Trust | Cardiff, United Kingdom | — |
| Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust | Doncaster, United Kingdom | — |
| Medway NHS Foundation Trust | Gillingham, United Kingdom | — |
| The Beatson West of Scotland Cancer Centre | Glasgow, United Kingdom | — |
| The Clatterbridge Cancer Centre NHS Foundation Trust | Liverpool, United Kingdom | — |
| The Princess Alexandra Hospital NHS Trust | London, United Kingdom | — |
| Barts Health NHS Trust, Royal London Hospital | London, United Kingdom | — |
| Kingston Hospital NHS Foundation Trust | London, United Kingdom | — |
| Royal Free London NHS Foundation Trust | London, United Kingdom | — |
| Guy's and St Thomas's NHS Foundation Trust | London, United Kingdom | — |
+ 4 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04067713