EICHOR
● Active Not Recruiting
First in Human Study of Ziftomenib in Relapsed or Refractory Acute Myeloid Leukemia
Condition: Advanced Malignant Neoplasm · Acute Myeloid Leukemia · Mixed Lineage Leukemia · Sponsor: Kura Oncology, Inc.
About this study
In this trial, ziftomenib, a menin-MLL(KMT2A) inhibitor, will be tested in patients for the first time. The trial includes a Main Study and four sub-studies. In the Main Study (including Phase 1a, Phase 1b, and Phase 2 portions), ziftomenib will be evaluated in patients with relapsed or refractory (R/R) acute myeloid leukemia (AML). The main study has completed enrollment. In Sub-studies 1 and 2, the effects of taking ziftomenib and other common drugs at the same time will be investigated in AML patients. In Sub-study 3, ziftomenib will be evaluated in patients with R/R acute lymphoblastic leukemia (ALL). In Sub-study 4, ziftomenib will be evaluated in patients with R/R AML with certain genetic mutations.
This description comes directly from the study's public registry record.
Talk to the study team
No contact information is available for this study as per the public registry record.
Always discuss trial participation with your own doctor first.
Locations (43)
| Banner MD Anderson Cancer Center | Gilbert, Arizona, United States | — |
| UCLA Ronald Reagan Medical Center | Los Angeles, California, United States | — |
| Mayo Clinic | Jacksonville, Florida, United States | — |
| Robert H. Lurie Comprehensive Cancer Center of Northwestern University | Chicago, Illinois, United States | — |
| University of Maryland Greenebaum Comprehensive Cancer Center | Baltimore, Maryland, United States | — |
| Massachusetts General Hospital | Boston, Massachusetts, United States | — |
| University of Michigan Hospitals | Ann Arbor, Michigan, United States | — |
| Karmanos Cancer Institute | Detroit, Michigan, United States | — |
| Mayo Clinic | Rochester, Minnesota, United States | — |
| Hackensack University Medical Center - John Theurer Cancer Center | Hackensack, New Jersey, United States | — |
| Roswell Park Comprehensive Cancer Center | Buffalo, New York, United States | — |
| Weill Cornell Medical College - NY Presbyterian Hospital | New York, New York, United States | — |
+ 31 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04067336