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Study identifier: NCT04034485 Synced from ClinicalTrials.gov · August 05, 2026
● Completed

Phase 3 Study to Evaluate the Efficacy and Safety of LIB003 With Evolocumab in HoFH

Condition: Homozygous Familial Hypercholesterolemia  ·  Sponsor: LIB Therapeutics LLC

PhasePhase 3
Planned participants65
Who can joinAll sexes, 10 Years to no upper limit
Healthy volunteersNo

About this study

To compare the safety, tolerability and LDL-C response after 24 Weeks of monthly (every 4 weeks \[Q4W\]) subcutaneous (SC) dosing of LIB003 300 mg with monthly (Q4W) SC dosing of 420 mg evolocumab (Repatha®) in patients with HoFH on stable diet and oral LDL-C-lowering drug therapy

This description comes directly from the study's public registry record.

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No contact information is available for this study as per the public registry record.

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Locations (12)

NorthShore University Health SystemEvanston, Illinois, United States
Metabolic & Atherosclerosis Research Center (MARC)Cincinnati, Ohio, United States
VMMC & Safdarjung HospitalDelhi, National Capital Territory of Delhi, India
CIMS Hospital Pvt. LtdAhmedabad, India
G.B. Pant Institute of Postgraduate Medical Education & ResearchNew Delhi, India
Department of Medicine, Hadassah University HospitalJerusalem, Israel
Rabin Medical Center, Beilinson Hospital,Petah Tikva, Israel
Lipid Clinic, Oslo University HospitalOslo, Norway
Carbohydrate and Lipid Metabolism Research UnitJohannesburg, Gauteng, South Africa
Division of Lipidology, Department of Medicine University of Cape TownCape Town, Western Province, South Africa
Ege University Medical SchoolIzmir, Bornova, Turkey (Türkiye)
Afyonkarahisar Health Sciences UniversityAfyonkarahisar, Turkey (Türkiye)

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