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Study identifier: NCT04030598 Synced from ClinicalTrials.gov · August 05, 2026
● Completed

A Study to Assess the Clinical Efficacy of Donidalorsen (Also Known as IONIS-PKK-LRx and ISIS 721744) in Participants With Hereditary Angioedema

Condition: Hereditary Angioedema  ·  Sponsor: Ionis Pharmaceuticals, Inc.

PhasePhase 2
Planned participants23
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study was to evaluate the clinical efficacy, safety, and tolerability of donidalorsen in participants with hereditary angioedema (HAE) type 1 (HAE-1), HAE type 2 (HAE-2), or HAE with normal C1-inhibitor (C1-INH) and to evaluate the effect of donidalorsen on plasma prekallikrein (PKK) and other relevant biomarkers.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (8)

Medical Research of ArizonaScottsdale, Arizona, United States
University of California San Diego (UCSD)San Diego, California, United States
AIRE Medical of Los AngelesSanta Monica, California, United States
Midwest Immunology ClinicalPlymouth, Minnesota, United States
Bernstein Clinical Research Center, LLCCincinnati, Ohio, United States
Penn State Hershey Medical CenterHershey, Pennsylvania, United States
AARA Research CenterDallas, Texas, United States
Amsterdam UMC, loc. AMCAmsterdam, Netherlands

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