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Testing the Combination of Cabozantinib, Nivolumab, and Ipilimumab (CaboNivoIpi) for Advanced Differentiated Thyroid Cancer
Condition: Differentiated Thyroid Gland Carcinoma · Follicular Variant Thyroid Gland Papillary Carcinoma · Poorly Differentiated Thyroid Gland Carcinoma · Sponsor: National Cancer Institute (NCI)
About this study
This phase II trial studies how well cabozantinib, nivolumab, and ipilimumab work in treating patients with differentiated thyroid cancer that does not respond to radioactive iodine and that worsened after treatment with a drug targeting the vascular endothelial growth factor receptor (VEGFR), a protein needed to form blood vessels. Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving cabozantinib, nivolumab and ipilimumab may work better than the usual approach consisting of chemotherapy with drugs such as doxorubicin, sorafenib, and lenvatinib for this type of thyroid cancer.
This description comes directly from the study's public registry record.
Talk to the study team
No contact information is available for this study as per the public registry record.
Always discuss trial participation with your own doctor first.
Locations (33)
| City of Hope Comprehensive Cancer Center | Duarte, California, United States | — |
| Los Angeles General Medical Center | Los Angeles, California, United States | — |
| USC / Norris Comprehensive Cancer Center | Los Angeles, California, United States | — |
| USC Norris Oncology/Hematology-Newport Beach | Newport Beach, California, United States | — |
| Moffitt Cancer Center-International Plaza | Tampa, Florida, United States | — |
| Moffitt Cancer Center - McKinley Campus | Tampa, Florida, United States | — |
| Moffitt Cancer Center | Tampa, Florida, United States | — |
| University of Kansas Clinical Research Center | Fairway, Kansas, United States | — |
| HaysMed | Hays, Kansas, United States | — |
| University of Kansas Cancer Center | Kansas City, Kansas, United States | — |
| The University of Kansas Cancer Center - Olathe | Olathe, Kansas, United States | — |
| University of Kansas Cancer Center-Overland Park | Overland Park, Kansas, United States | — |
+ 21 more locations — full list on the registry record.
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