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Study identifier: NCT03886246 Synced from ClinicalTrials.gov · August 03, 2026
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Effisayil™ ON: A Study to Test Long-term Treatment With Spesolimab in People With Generalized Pustular Psoriasis Who Took Part in a Previous Study

Condition: Generalized Pustular Psoriasis  ·  Sponsor: LEO Pharma

PhasePhase 2
Planned participants131
Who can joinAll sexes, 12 Years to 75 Years
Healthy volunteersNo

About this study

This study is open to people with generalized pustular psoriasis (GPP). People can only take part if they have completed treatment in a previous study with spesolimab (1368-0013 or 1368-0027). The goal of this study is to find out how well people with GPP tolerate long-term treatment with spesolimab. The study also tests whether spesolimab helps improve GPP symptoms and how quickly the symptoms improve after a flare-up. Every participant gets spesolimab for almost 5 years (252 weeks). Depending on their symptoms and whether they had a GPP flare during the previous trial, they get spesolimab every few weeks. When participants have a GPP flare during this trial, they get spesolimab as an infusion into a vein. Participants visit their doctors regularly. During these visits, the doctors collect information on any health problems of the participants. To assess the study endpoints, doctors regularly check participants' skin.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (58)

Oakland Hills DermatologyAuburn Hills, Michigan, United States
Icahn School of Medicine at Mount SinaiNew York, New York, United States
Hospital Italiano de Buenos AiresCABA, Argentina
Cliniques Universitaires Saint-LucBrussels, Belgium
Clínica Dermacross S.A.Vitacura, Chile
Sun yet-sen Memorial Hospital, Sun yet-sen UnivesityGuangzhou, China
The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou, China
Shanghai Skin Disease HospitalShanghai, China
Huashan Hospital, Fudan UniversityShanghai, China
Second Affiliated Hospital of Xi'an JiaoTong UniversityXi'an, China
HOP Saint-AndréBordeaux, France
Hôpital de l'ArchetNice, France

+ 46 more locations — full list on the registry record.

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