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Birinapant and Intensity Modulated Re-Irradiation Therapy in Treating Patients With Locally Recurrent Head and Neck Squamous Cell Carcinoma
Condition: Locally Recurrent Head and Neck Squamous Cell Carcinoma · Nasopharyngeal Squamous Cell Carcinoma · Sinonasal Squamous Cell Carcinoma · Sponsor: National Cancer Institute (NCI)
About this study
This phase I trial studies the side effects and best dose of birinapant when given together with intensity modulated re-irradiation therapy (IMRRT) in treating patients with head and neck squamous cell carcinoma that has come back at or near the same place as the original (primary) tumor (locally recurrent). Birinapant may stop the growth of tumor cells by blocking inhibitor of apoptosis (IAP), a protein needed for tumor cell survival. IMRRT uses thin beams of radiation of different intensities that are aimed at the tumor from many angles. This type of re-irradiation therapy reduces the damage to healthy tissue near the tumor. Giving birinapant with IMRRT may lower the chance of head and neck squamous cell carcinoma growing or spreading.
This description comes directly from the study's public registry record.
Talk to the study team
No contact information is available for this study as per the public registry record.
Always discuss trial participation with your own doctor first.
Locations (33)
| University of Alabama at Birmingham Cancer Center | Birmingham, Alabama, United States | — |
| Los Angeles General Medical Center | Los Angeles, California, United States | — |
| USC / Norris Comprehensive Cancer Center | Los Angeles, California, United States | — |
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange, California, United States | — |
| UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables, Florida, United States | — |
| UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach, Florida, United States | — |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami, Florida, United States | — |
| UM Sylvester Comprehensive Cancer Center at Plantation | Plantation, Florida, United States | — |
| Moffitt Cancer Center-International Plaza | Tampa, Florida, United States | — |
| Moffitt Cancer Center - McKinley Campus | Tampa, Florida, United States | — |
| Moffitt Cancer Center | Tampa, Florida, United States | — |
| University of Kansas Clinical Research Center | Fairway, Kansas, United States | — |
+ 21 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT03803774