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Study identifier: NCT03767244 Synced from ClinicalTrials.gov · August 02, 2026
● Active Not Recruiting

A Study of Apalutamide in Participants With High-Risk, Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy

Condition: Prostatic Neoplasms  ·  Sponsor: Janssen Research & Development, LLC

PhasePhase 3
Planned participants2517
Who can joinMale, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to determine if treatment with apalutamide plus androgen deprivation therapy (ADT) before and after radical prostatectomy (RP) with pelvic lymph node dissection (pLND) in participants with high-risk localized or locally advanced prostate cancer results in an improvement in pathological complete response (pCR) rate and metastasis-free survival (MFS) as compared to placebo plus ADT.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

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Locations (203)

UC San Diego Moores Cancer CenterLa Jolla, California, United States
University of Southern CaliforniaLos Angeles, California, United States
Cedars Sinai Medical CenterLos Angeles, California, United States
University of California Los AngelesLos Angeles, California, United States
University of California Irvine Medical Center Chao Family Comprehensive Cancer CenterOrange, California, United States
UC Davis Medical CenterSacramento, California, United States
AdventHealth Medical Group Urology of DenverDenver, Colorado, United States
Colorado Clinical ResearchLakewood, Colorado, United States
Stamford HospitalStamford, Connecticut, United States
Urology Specialists LLCHialeah, Florida, United States
Mayo Clinic - Division Of Hematology/oncologyJacksonville, Florida, United States
Miami Cancer Institute at Baptist Health / Baptist Health Medical GroupMiami, Florida, United States

+ 191 more locations — full list on the registry record.

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