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Study identifier: NCT03742895 Synced from ClinicalTrials.gov · August 03, 2026
● Active Not Recruiting

Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated, Homologous Recombination Repair Mutation (HRRm) or Homologous Recombination Deficiency (HRD) Positive Advanced Cancer (MK-7339-002 / LYNK-002)

Condition: Advanced Solid Neoplasms  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 2
Planned participants329
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will evaluate the efficacy and safety of olaparib (MK-7339) monotherapy in participants with multiple types of advanced cancer (unresectable and/or metastatic) that: 1) have progressed or been intolerant to standard of care therapy; and 2) are positive for homologous recombination repair mutation (HRRm) or homologous recombination deficiency (HRD).

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (130)

The University of Arizona Cancer Center - North Campus ( Site 0011)Tucson, Arizona, United States
St Joseph Heritage Healthcare-Oncology ( Site 0056)Fullerton, California, United States
Cedars Sinai Medical Center ( Site 0002)Los Angeles, California, United States
UCSF Helen Diller Family Comprehensive Cancer Center ( Site 0007)San Francisco, California, United States
Rocky Mountain Regional Veterans Affairs Medical Center ( Site 0092)Aurora, Colorado, United States
Winship Cancer Institute of Emory University ( Site 0025)Atlanta, Georgia, United States
Augusta University ( Site 0028)Augusta, Georgia, United States
Markey Cancer Center ( Site 0018)Lexington, Kentucky, United States
University of Maryland ( Site 0050)Baltimore, Maryland, United States
Weinberg Cancer Institute at Franklin Square ( Site 0054)Baltimore, Maryland, United States
University of Massachusetts ( Site 0017)Worcester, Massachusetts, United States
Henry Ford Health System ( Site 0060)Detroit, Michigan, United States

+ 118 more locations — full list on the registry record.

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