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Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Bacillus Calmette-Guerin (BCG) in High-Risk Non-Muscle Invasive Bladder Cancer (HR NMIBC) (MK-3475-676/KEYNOTE-676)
Condition: High-risk Non-muscle Invasive Bladder Cancer · Sponsor: Merck Sharp & Dohme LLC
About this study
Researchers are looking for new ways to treat high-risk non muscle invasive bladder cancer (HR NMIBC). NMIBC is cancer in the tissue that lines the inside of the bladder but has not spread to the bladder muscle or outside of the bladder. High-risk means NMIBC may have a high chance of getting worse or coming back after treatment. The goals of this study are to learn: 1. If more people who receive pembrolizumab with Bacillus Calmette-Guerin (BCG) have no signs of cancer in their body and live longer without the cancer growing, spreading, or coming back compared to people who receive BCG alone. 2. About the safety and how well people tolerate BCG alone or in combination with pembrolizumab.
This description comes directly from the study's public registry record.
Talk to the study team
No contact information is available for this study as per the public registry record.
Always discuss trial participation with your own doctor first.
Locations (209)
| Alaska Urological Institute dba Alaska Clinical Research Center ( Site 1083) | Anchorage, Alaska, United States | — |
| Mayo Clinic in Arizona - Phoenix ( Site 1094) | Phoenix, Arizona, United States | — |
| Del Sol Research Management, LLC ( Site 1096) | Tucson, Arizona, United States | — |
| UCLA Hematology/Oncology - Westwood (Building 200 Suite 140)-Department of Urology/Institute of Uro ( Site 1052) | Los Angeles, California, United States | — |
| University of California Irvine Medical Center ( Site 1061) | Orange, California, United States | — |
| Genesis Research LLC ( Site 1065) | Torrance, California, United States | — |
| Colorado Clinical Research ( Site 1100) | Lakewood, Colorado, United States | — |
| Urological Research Network ( Site 1106) | Hialeah, Florida, United States | — |
| Mayo Clinic in Florida-Urology ( Site 1097) | Jacksonville, Florida, United States | — |
| University of Miami Hospital and Clinics, Sylvester Cancer Center ( Site 1056) | Miami, Florida, United States | — |
| Woodlands Medical Specialists, PA ( Site 8002) | Pensacola, Florida, United States | — |
| Emory School of Medicine ( Site 1076) | Atlanta, Georgia, United States | — |
+ 197 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT03711032