EICHOR
● Recruiting
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
Condition: Advanced/Metastatic Solid Tumors · Colorectal Cancer · Gastric Cancer · Sponsor: Merus B.V.
About this study
This is a Phase 1/2 open-label, multi-center, multi-national study with an initial dose escalation part to determine the recommended Phase II dose (RP2D) of MCLA-158 single agent in patients with mCRC. The dose escalation part has been completed and the RP2D will be further evaluated in an expansion part of the study. Cohorts of selected solid tumor indications for which there is evidence of EGFR dependency and potential sensitivity to EGFR inhibition will be evaluated including head and neck cancer and metastatic colorectal cancer (mCRC). The study will further assess the safety, tolerability, PK, PD, immunogenicity, and anti-tumor activity of MCLA-158 in monotherapy or in combination with other therapies.
This description comes directly from the study's public registry record.
Talk to the study team
Silke Thiele, MD · +31 85 016 2500 · enquiries-merus@genmab.com
Eduardo Pennella, MD · +1 617 401 4499 · USenquiries-merus@genmab.com
Always discuss trial participation with your own doctor first.
Locations (54)
| UCSD | La Jolla, California, United States | Recruiting |
| USC Norris Comprehensive Cancer Center | Los Angeles, California, United States | Active Not Recruiting |
| Sharp Healthcare | San Diego, California, United States | Recruiting |
| Rocky Mountain Cancer Centers | Lone Tree, Colorado, United States | Recruiting |
| Florida Cancer Specialists | Fort Myers, Florida, United States | Active Not Recruiting |
| University of Florida | Gainesville, Florida, United States | Recruiting |
| Sarah Cannon Research Institute (Lake Nona) | Orlando, Florida, United States | Recruiting |
| Emory University | Atlanta, Georgia, United States | Recruiting |
| Massachusetts General Hospital - Dana Farber | Boston, Massachusetts, United States | Recruiting |
| Karmanos Cancer Institute | Detroit, Michigan, United States | Completed |
| SSM Health Saint Louis University Hospital | St Louis, Missouri, United States | Completed |
| Washington University School of Medicine at St Louis | St Louis, Missouri, United States | Recruiting |
+ 42 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT03526835