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Study identifier: NCT03425838 Synced from ClinicalTrials.gov · August 05, 2026
● Active Not Recruiting

Endocrine Therapy Plus CDK4/6 in First or Second Line for Hormone (SONIA) Receptor Positive Advanced Breast Cancer

Condition: Breast Neoplasm Female  ·  Sponsor: Borstkanker Onderzoek Groep

PhasePhase 3
Planned participants1050
Who can joinFemale, 18 Years to no upper limit
Healthy volunteersNo

About this study

Given the uncertain benefit in efficacy of adding CDK 4/6 to first rather than second line endocrine treatment, the aim of this project is to evaluate whether the sequence of an aromatase inhibitor plus CDK 4/6 in first line followed by fulvestrant in second line is superior to the sequence of an aromatase inhibitor in first line followed by fulvestrant plus CDK4/6 in second line.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

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Locations (72)

Jeroen Bosch Ziekenhuis's-Hertogenbosch, Netherlands
NoordwestziekenhuisgroepAlkmaar, Netherlands
ZGTAlmelo, Netherlands
FlevoziekenhuisAlmere Stad, Netherlands
Meander Medisch CentrumAmersfoort, Netherlands
Ziekenhuis AmstellandAmstelveen, Netherlands
Nki - AvlAmsterdam, Netherlands
VUmcAmsterdam, Netherlands
AMCAmsterdam, Netherlands
BovenIJ ZiekenhuisAmsterdam, Netherlands
OLVGAmsterdam, Netherlands
Gelre ziekenhuizenApeldoorn, Netherlands

+ 60 more locations — full list on the registry record.

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