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● Completed
Radiation Therapy With Durvalumab or Cetuximab in Treating Patients With Locoregionally Advanced Head and Neck Cancer Who Cannot Take Cisplatin
Condition: Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 · Head and Neck Squamous Cell Carcinoma · Hypopharyngeal Squamous Cell Carcinoma · Sponsor: National Cancer Institute (NCI)
About this study
This phase II/III trial studies how well radiation therapy works with durvalumab or cetuximab in treating patients with head and neck cancer that has spread to a local and/or regional area of the body who cannot take cisplatin. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Cetuximab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. It is not known if radiation therapy with durvalumab will work better than the usual therapy of radiation therapy with cetuximab in treating patients with head and neck cancer.
This description comes directly from the study's public registry record.
Talk to the study team
No contact information is available for this study as per the public registry record.
Always discuss trial participation with your own doctor first.
Locations (256)
| University of Alabama at Birmingham Cancer Center | Birmingham, Alabama, United States | — |
| University of South Alabama Mitchell Cancer Institute | Mobile, Alabama, United States | — |
| Banner MD Anderson Cancer Center | Gilbert, Arizona, United States | — |
| CTCA at Western Regional Medical Center | Goodyear, Arizona, United States | — |
| Banner University Medical Center - Tucson | Tucson, Arizona, United States | — |
| University of Arizona Cancer Center-North Campus | Tucson, Arizona, United States | — |
| Kaiser Permanente-Deer Valley Medical Center | Antioch, California, United States | — |
| Sutter Cancer Centers Radiation Oncology Services-Auburn | Auburn, California, United States | — |
| Alta Bates Summit Medical Center-Herrick Campus | Berkeley, California, United States | — |
| City of Hope Comprehensive Cancer Center | Duarte, California, United States | — |
| Kaiser Permanente Dublin | Dublin, California, United States | — |
| Kaiser Permanente-Fremont | Fremont, California, United States | — |
+ 244 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT03258554