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Study identifier: NCT03165734 Synced from ClinicalTrials.gov · August 03, 2026
● Active Not Recruiting

A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis

Condition: Primary Myelofibrosis · Post-polycythemia Vera Myelofibrosis · Post-essential Thrombocythemia Myelofibrosis  ·  Sponsor: Swedish Orphan Biovitrum

PhasePhase 3
Planned participants407
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study (study ID PAC203 North America; PAC303 ex-North America) is evaluating 200 mg BID of pacritinib compared to physician's choice (P/C) therapy in patients with MF and severe thrombocytopenia (platelet count \<50,000/μL). Approximately 399 patients in total will be enrolled, randomized 2:1 to either pacritinib (approximately 266 patients) or to P/C therapy (approximately 133 patients) Condition or disease: Primary Myelofibrosis/Post-Polycythemia Vera Myelofibrosis/ Post-essential Thrombocythemia Myelofibrosis Intervention/treatment: Drug-Pacritinib

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

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Locations (207)

University of Alabama at Birmingham, (UAB) Hospital, Comprehensive Cancer CenterBirmingham, Alabama, United States
Mayo Clinic HospitalPhoenix, Arizona, United States
City of HopeDuarte, California, United States
USC Norris Comprehensive Cancer CenterLos Angeles, California, United States
UCLA David Geffen School of MedicineLos Angeles, California, United States
University of Colorado Cancer CenterAurora, Colorado, United States
Rocky Mountain Cancer Centers (US Oncology/McKesson)Boulder, Colorado, United States
Yale School of MedicineNew Haven, Connecticut, United States
Georgetown University HospitalWashington D.C., District of Columbia, United States
George Washington University-Medical Faculty AssociatesWashington D.C., District of Columbia, United States
Cleveland Clinic FloridaWeston, Florida, United States
Northwestern Memorial HospitalChicago, Illinois, United States

+ 195 more locations — full list on the registry record.

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