EICHOR
● Completed
A Study to Compare Tivozanib Hydrochloride to Sorafenib in Participants With Refractory Advanced Renal Cell Carcinoma (RCC)
Condition: Carcinoma, Renal Cell · Sponsor: AVEO Pharmaceuticals, Inc.
About this study
This is a Phase 3, open-label, randomized, controlled, multi-national, multi-center, parallel-arm study comparing tivozanib to sorafenib in participants with refractory advanced renal cell carcinoma (RCC). Participants will be randomized (1:1) to treatment with tivozanib or sorafenib. Participants will be stratified by International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk category (favorable; intermediate; poor) and prior therapy (two prior vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR TKI); a prior checkpoint inhibitor \[programmed cell death -1 protein (PD-1) or PD-1 ligand (PD1-L) inhibitor\] plus a prior VEGFR TKI; a prior VEGFR TKI plus any other systemic agent). All participants will be evaluated for progression free survival, overall survival, objective response rate, and the duration of response as well as safety and tolerability. Pharmacokinetic (PK) analyses are also included in study.
This description comes directly from the study's public registry record.
Talk to the study team
No contact information is available for this study as per the public registry record.
Always discuss trial participation with your own doctor first.
Locations (191)
| University Of UA Cancer Center(UACC)/DH-SJHMC | Phoenix, Arizona, United States | — |
| Arizona Oncology Associates, PC - HAL | Phoenix, Arizona, United States | — |
| Arizona Oncology - Phoenix - Deer Valley Women's Center Loca | Phoenix, Arizona, United States | — |
| Arizona Oncology - Scottsdale | Scottsdale, Arizona, United States | — |
| City of Hope Comprehensive Breast Cancer Center | Duarte, California, United States | — |
| Long Beach Memorial Medical Center | Fountain Valley, California, United States | — |
| Marin Cancer Care | Greenbrae, California, United States | — |
| UCLA | Los Angeles, California, United States | — |
| MedStar Georgetown University Hospital | Washington D.C., District of Columbia, United States | — |
| University of Miami Sylvester Comprehensive Cancer Center | Miami, Florida, United States | — |
| Mount Sinai Comprehensive Cancer Center | Miami Beach, Florida, United States | — |
| Loyola University Medical Center | Maywood, Illinois, United States | — |
+ 179 more locations — full list on the registry record.
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