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Physician/Patient Choice of Either High-Dose Recombinant Interferon Alfa-2B or Ipilimumab, Versus Pembrolizumab in Treating Patients With Stage III-IV High Risk Melanoma That Has Been Removed by Surgery
Condition: Clinical Stage III Cutaneous Melanoma AJCC v8 · Clinical Stage IV Cutaneous Melanoma AJCC v8 · Metastatic Cutaneous Melanoma · Sponsor: National Cancer Institute (NCI)
About this study
This randomized phase III trial studies how well pembrolizumab works compared with the current standard of care, physician/patient choice of either high-dose recombinant interferon alfa-2B or ipilimumab, in treating patients with stage III-IV melanoma that has been removed by surgery but is likely to come back or spread. High-dose recombinant interferon alfa-2B may help shrink or slow the growth of melanoma. Immunotherapy with monoclonal antibodies, such as ipilimumab and pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. It is not yet known whether pembrolizumab is more effective than the current standard of care in treating patients with melanoma.
This description comes directly from the study's public registry record.
Talk to the study team
No contact information is available for this study as per the public registry record.
Always discuss trial participation with your own doctor first.
Locations (576)
| University of Alabama at Birmingham Cancer Center | Birmingham, Alabama, United States | — |
| Cancer Center at Saint Joseph's | Phoenix, Arizona, United States | — |
| Virginia G Piper Cancer Care-Del Camino | Scottsdale, Arizona, United States | — |
| Banner University Medical Center - Tucson | Tucson, Arizona, United States | — |
| University of Arizona Cancer Center-North Campus | Tucson, Arizona, United States | — |
| University of Arkansas for Medical Sciences | Little Rock, Arkansas, United States | — |
| Highlands Oncology Group - Rogers | Rogers, Arkansas, United States | — |
| Kaiser Permanente-Anaheim | Anaheim, California, United States | — |
| Sutter Auburn Faith Hospital | Auburn, California, United States | — |
| Kaiser Permanente-Baldwin Park | Baldwin Park, California, United States | — |
| Kaiser Permanente-Bellflower | Bellflower, California, United States | — |
| UC Irvine Health Cancer Center-Newport | Costa Mesa, California, United States | — |
+ 564 more locations — full list on the registry record.
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