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A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients With Advanced Melanoma
Condition: Stage III Cutaneous Melanoma AJCC v7 · Stage IV Cutaneous Melanoma AJCC v6 and v7 · Sponsor: National Cancer Institute (NCI)
About this study
This phase II/III trial studies the side effects of nivolumab and ipilimumab when given together with or without sargramostim and to see how well they work in treating patients with stage III-IV melanoma that cannot be removed by surgery (unresectable) and that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). Immunotherapy with monoclonal antibodies, such as ipilimumab and nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Colony-stimulating factors, such as sargramostim, may increase the production of white blood cells. It is not yet known whether nivolumab and ipilimumab are more effective with or without sargramostim in treating patients with melanoma.
This description comes directly from the study's public registry record.
Talk to the study team
No contact information is available for this study as per the public registry record.
Always discuss trial participation with your own doctor first.
Locations (764)
| University of Alabama at Birmingham Cancer Center | Birmingham, Alabama, United States | — |
| Kingman Regional Medical Center | Kingman, Arizona, United States | — |
| CARTI Cancer Center | Little Rock, Arkansas, United States | — |
| John L McClellan Memorial Veterans Hospital | Little Rock, Arkansas, United States | — |
| Kaiser Permanente-Anaheim | Anaheim, California, United States | — |
| Kaiser Permanente-Deer Valley Medical Center | Antioch, California, United States | — |
| PCR Oncology | Arroyo Grande, California, United States | — |
| Sutter Auburn Faith Hospital | Auburn, California, United States | — |
| Sutter Cancer Centers Radiation Oncology Services-Auburn | Auburn, California, United States | — |
| Kaiser Permanente-Baldwin Park | Baldwin Park, California, United States | — |
| Kaiser Permanente-Bellflower | Bellflower, California, United States | — |
| Alta Bates Summit Medical Center-Herrick Campus | Berkeley, California, United States | — |
+ 752 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT02339571