Phase Ib Study of SAR650984 in Combination With Carfilzomib for Treatment of Relapsed or Refractory Multiple Myeloma
Condition: Multiple Myeloma · Sponsor: Thomas Martin, MD
About this study
This phase Ib trial studies the side effects and best dose of isatuximab when given together with carfilzomib with or without dexamethasone and lenalidomide in treating patients with multiple myeloma that has returned after a period of improvement (relapsed) or has not respond to previous treatment (refractory). Immunotherapy with monoclonal antibodies, such as isatuximab, may induce changes in the body's immune system and may interfere with the ability of tumor cells to grow and spread. Carfilzomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as dexamethasone and lenalidomide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving isatuximab and carfilzomib with or without dexamethasone and lenalidomide may be a better treatment for patients with multiple myeloma.
This description comes directly from the study's public registry record.
Talk to the study team
No contact information is available for this study as per the public registry record.
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Locations (6)
| University of California, San Francisco | San Francisco, California, United States | — |
| Colorado Blood Cancer Institute | Denver, Colorado, United States | — |
| Hackensack University Medical Center | Hackensack, New Jersey, United States | — |
| Icahn School of Medicine at Mount Sinai | New York, New York, United States | — |
| Sarah Cannon Cancer Center | Nashville, Tennessee, United States | — |
| Princess Margaret Cancer Centre | Toronto, Ontario, Canada | — |
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Source record: clinicaltrials.gov/study/NCT02332850