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Study identifier: NCT02254863 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

UCB Transplant of Inherited Metabolic Diseases With Administration of Intrathecal UCB Derived Oligodendrocyte-Like Cells

Condition: Adrenoleukodystrophy · Batten Disease · Mucopolysaccharidosis II  ·  Sponsor: Joanne Kurtzberg, MD

PhasePhase 1
Planned participants40
Who can joinAll sexes, 1 Week to 22 Years
Healthy volunteersNo

About this study

The primary objective of the study is to determine the safety and feasibility of intrathecal administration of DUOC-01 as an adjunctive therapy in patients with inborn errors of metabolism who have evidence of early demyelinating disease in the central nervous system (CNS) who are undergoing standard treatment with unrelated umbilical cord blood transplantation (UCBT). The secondary objective of the study is to describe the efficacy of UCBT with intrathecal administration of DUOC-01 in these patients.

This description comes directly from the study's public registry record.

Talk to the study team

Sydney Crane, RN  ·  cordbloodtherapyinfo@dm.duke.edu

Erin Arbuckle  ·  cordbloodtherapyinfo@dm.duke.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Duke University Medical CenterDurham, North Carolina, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT02254863