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Azacitidine With or Without Lenalidomide or Vorinostat in Treating Patients With Higher-Risk Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia
Condition: Chronic Myelomonocytic Leukemia · Chronic Myelomonocytic Leukemia-1 · Chronic Myelomonocytic Leukemia-2 · Sponsor: National Cancer Institute (NCI)
About this study
This randomized phase II/III trial studies how well azacitidine works with or without lenalidomide or vorinostat in treating patients with higher-risk myelodysplastic syndromes or chronic myelomonocytic leukemia. Drugs used in chemotherapy, such as azacitidine, work in different ways to stop the growth of cancer cells, either by killing the cells, stopping them from dividing, or by stopping them from spreading. Lenalidomide may stop the growth of cancer cells by stopping blood flow to the cancer. Vorinostat may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. It is not yet known whether azacitidine is more effective with or without lenalidomide or vorinostat in treating myelodysplastic syndromes or chronic myelomonocytic leukemia.
This description comes directly from the study's public registry record.
Talk to the study team
No contact information is available for this study as per the public registry record.
Always discuss trial participation with your own doctor first.
Locations (294)
| University of Alabama at Birmingham Cancer Center | Birmingham, Alabama, United States | — |
| University of South Alabama Mitchell Cancer Institute | Mobile, Alabama, United States | — |
| Mayo Clinic in Arizona | Scottsdale, Arizona, United States | — |
| Banner University Medical Center - Tucson | Tucson, Arizona, United States | — |
| University of Arizona Cancer Center-North Campus | Tucson, Arizona, United States | — |
| John L McClellan Memorial Veterans Hospital | Little Rock, Arkansas, United States | — |
| Kaiser Permanente-Deer Valley Medical Center | Antioch, California, United States | — |
| City of Hope Comprehensive Cancer Center | Duarte, California, United States | — |
| USC / Norris Comprehensive Cancer Center | Los Angeles, California, United States | — |
| Kaiser Permanente-Oakland | Oakland, California, United States | — |
| Stanford Cancer Institute Palo Alto | Palo Alto, California, United States | — |
| Kaiser Permanente-Richmond | Richmond, California, United States | — |
+ 282 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT01522976