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Study identifier: NCT01275677 Synced from ClinicalTrials.gov · August 02, 2026
● Completed

Chemotherapy With or Without Trastuzumab After Surgery in Treating Women With Invasive Breast Cancer

Condition: HER2/Neu Positive · Progesterone Receptor Positive · Recurrent Breast Carcinoma  ·  Sponsor: National Cancer Institute (NCI)

PhasePhase 3
Planned participants3270
Who can joinFemale, 18 Years to no upper limit
Healthy volunteersNo

About this study

This randomized phase III clinical trial studies chemotherapy with or without trastuzumab after surgery to see how well they work in treating women with invasive breast cancer. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) and giving chemotherapy after surgery may kill more tumor cells. Monoclonal antibodies, such as trastuzumab, can block cancer growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether combination chemotherapy is more effective with trastuzumab in treating breast cancer.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (1283)

Northeast Alabama Regional Medical CenterAnniston, Alabama, United States
Providence HospitalMobile, Alabama, United States
University of South Alabama Mitchell Cancer InstituteMobile, Alabama, United States
Alaska Breast Care and Surgery LLCAnchorage, Alaska, United States
Alaska Women's Cancer CareAnchorage, Alaska, United States
Anchorage Oncology CentreAnchorage, Alaska, United States
Katmai Oncology GroupAnchorage, Alaska, United States
Providence Alaska Medical CenterAnchorage, Alaska, United States
Fairbanks Memorial HospitalFairbanks, Alaska, United States
Arizona Oncology Associates-Biltmore Cancer CenterPhoenix, Arizona, United States
Virginia G Piper Cancer Care-Del CaminoScottsdale, Arizona, United States
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - JonesboroJonesboro, Arkansas, United States

+ 1271 more locations — full list on the registry record.

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