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Study identifier: NCT01274338 Synced from ClinicalTrials.gov · August 02, 2026
● Active Not Recruiting

Ipilimumab or High-Dose Interferon Alfa-2b in Treating Patients With High-Risk Stage III-IV Melanoma That Has Been Removed by Surgery

Condition: Melanoma of Unknown Primary · Recurrent Melanoma · Stage IIIB Cutaneous Melanoma AJCC v7  ·  Sponsor: National Cancer Institute (NCI)

PhasePhase 3
Planned participants1673
Who can joinAll sexes, 12 Years to no upper limit
Healthy volunteersNo

About this study

This randomized phase III trial studies ipilimumab to see how well it works compared to high-dose interferon alfa-2b in treating patients with high-risk stage III-IV melanoma that has been removed by surgery. Immunotherapy with monoclonal antibodies, such as ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Interferon alfa-2b may interfere with the growth of tumor cells and slow the growth of melanoma and other cancers. It is not yet known whether ipilimumab is more effective than interferon alfa-2b in treating patients with melanoma.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (938)

University of Alabama at Birmingham Cancer CenterBirmingham, Alabama, United States
Providence HospitalMobile, Alabama, United States
University of South Alabama Mitchell Cancer InstituteMobile, Alabama, United States
Alaska Regional HospitalAnchorage, Alaska, United States
Providence Alaska Medical CenterAnchorage, Alaska, United States
Fairbanks Memorial HospitalFairbanks, Alaska, United States
Banner MD Anderson Cancer CenterGilbert, Arizona, United States
University of Arizona Cancer Center-Orange Grove CampusTucson, Arizona, United States
Banner University Medical Center - TucsonTucson, Arizona, United States
University of Arizona Cancer Center-North CampusTucson, Arizona, United States
Mercy Hospital Fort SmithFort Smith, Arkansas, United States
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - JonesboroJonesboro, Arkansas, United States

+ 926 more locations — full list on the registry record.

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