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Study identifier: NCT01142388 Synced from ClinicalTrials.gov · August 02, 2026
● Active Not Recruiting

Paclitaxel With or Without Cixutumumab as Second-Line Therapy in Treating Patients With Metastatic Esophageal Cancer or Gastroesophageal Junction Cancer

Condition: Metastatic Esophageal Adenocarcinoma · Metastatic Esophageal Squamous Cell Carcinoma · Metastatic Gastroesophageal Junction Adenocarcinoma  ·  Sponsor: National Cancer Institute (NCI)

PhasePhase 2
Planned participants94
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This randomized phase II trial studies how well paclitaxel with or without cixutumumab works in treating patients with esophageal cancer or gastroesophageal junction cancer that has spread to other places in the body (metastatic). Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Cixutumumab may kill cancer cells by blocking the action of a protein needed for cancer cell growth. Giving paclitaxel with or without cixutumumab may kill more tumor cells.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (232)

Mayo Clinic in ArizonaScottsdale, Arizona, United States
Stanford Cancer Institute Palo AltoPalo Alto, California, United States
The Medical Center of AuroraAurora, Colorado, United States
Boulder Community Foothills HospitalBoulder, Colorado, United States
Penrose-Saint Francis HealthcareColorado Springs, Colorado, United States
AdventHealth PorterDenver, Colorado, United States
Presbyterian - Saint Lukes Medical Center - Health OneDenver, Colorado, United States
Saint Joseph Hospital - Cancer Centers of ColoradoDenver, Colorado, United States
Rose Medical CenterDenver, Colorado, United States
Western States Cancer Research NCORPDenver, Colorado, United States
Swedish Medical CenterEnglewood, Colorado, United States
Saint Mary's Hospital and Regional Medical CenterGrand Junction, Colorado, United States

+ 220 more locations — full list on the registry record.

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