A Study of Trastuzumab Emtansine (T-DM1) Plus Pertuzumab/Pertuzumab Placebo Versus Trastuzumab [Herceptin] Plus a Taxane in Participants With Metastatic Breast Cancer (MARIANNE)
Condition: Breast Cancer · Sponsor: Hoffmann-La Roche
About this study
This randomized, 3-arm, multicenter, phase III study will evaluate the efficacy and safety of trastuzumab emtansine (T-DM1) with pertuzumab or trastuzumab emtansine (T-DM1) with pertuzumab-placebo (blinded for pertuzumab), versus the combination of trastuzumab (Herceptin) plus taxane (docetaxel or paclitaxel) in participants with HER2-positive progressive or recurrent locally advanced or previously untreated metastatic breast cancer. Participants will be randomized to 1 of 3 treatment arms (Arms A, B or C). Arm A will be open-label, whereas Arms B and C will be blinded.
This description comes directly from the study's public registry record.
Talk to the study team
No contact information is available for this study as per the public registry record.
Always discuss trial participation with your own doctor first.
Locations (257)
| Uni of Arkansas For Medical Sciences; Arkansas Cancer Research Center | Little Rock, Arkansas, United States | — |
| Scripps Cancer Center | La Jolla, California, United States | — |
| University of California; Moores Cancer Center | La Jolla, California, United States | — |
| Clnc L Trials & Rsch Assoc-Inc | Montebello, California, United States | — |
| Southern California Kaiser Permanente | San Diego, California, United States | — |
| Breastlink Medical Group Inc | Santa Ana, California, United States | — |
| Kaiser Permanente; Oncology Clinical Trials | Vallejo, California, United States | — |
| Smilow Cancer Hospital at Yale New Haven | New Haven, Connecticut, United States | — |
| Innovative Medical Research of South Florida | Aventura, Florida, United States | — |
| Northwest Oncology/ Hematology Assoc. | Coral Springs, Florida, United States | — |
| Florida Cancer Specialists; SCRI | Fort Myers, Florida, United States | — |
| Mayo Clinic-Jacksonville | Jacksonville, Florida, United States | — |
+ 245 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT01120184