EICHOR
● Completed
Genetics of Type 2 Diabetes in West Africans
Condition: Hypertension · Diabetes · Sponsor: National Human Genome Research Institute (NHGRI)
About this study
Background: * Type 2 diabetes (T2D) and associated complications are major contributors to the global disease burden. T2D is already a major health threat in populations in developed countries and is rapidly taking hold in the developing world. * It is believed that understanding the complex interplay between genetic and lifestyle characteristics in the etiology of T2D and related complications will lead to the development of better preventive and therapeutic strategies. In Addition, the results of this project will facilitate our understanding of causes of diabetes in African Americans, other US and world populations Objectives: * To conduct a genome-wide association study (GWAS) to identify susceptibility genetic variants for diabetes among the Yoruba people in Ibadan, Nigeria. * To enroll and examine 300 unrelated cases of T2D and 300 ethnicity-matched Yoruba controls. * To conduct resequencing of positional candidate gene/loci to identify likely functional variants in a subset of the cohort. * To conduct replication studies of the top-100 scoring variants in three independent African and European ancestry samples. * To investigate whether diabetes-associated variants discovered in European populations increase diabetes risk in West Africans. Eligibility: * Patients 18 years of age with confirmed T2D who are newly diagnosed or on treatment of Yoruba ethnicity in Ibadan, Nigeria. Control subjects are nondiabetics ethnically matched to patients. Design: * The study de…
This description comes directly from the study's public registry record.
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Locations (5)
| University of Ghana | Accra, Ghana | — |
| University of Science and Tech | Kumasi, Ghana | — |
| University of Nigeria | Enugu, Nigeria | — |
| University of Ibadan | Ibadan, Nigeria | — |
| University of Lagos | Lagos, Nigeria | — |
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Source record: clinicaltrials.gov/study/NCT00837122