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Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Condition: Neck Squamous Cell Carcinoma of Unknown Primary · Recurrent Hypopharyngeal Squamous Cell Carcinoma · Recurrent Laryngeal Squamous Cell Carcinoma · Sponsor: National Cancer Institute (NCI)
About this study
This randomized phase III trial studies chemotherapy to see how well it works with or without bevacizumab in treating patients with head and neck squamous cell carcinoma that has come back (recurrent) or that has spread to other parts of the body (metastatic). Drugs used in chemotherapy, such as docetaxel, cisplatin, carboplatin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as bevacizumab, may interfere with the ability of tumor cells to grow and spread. Bevacizumab may also make tumor cells more sensitive to chemotherapy and stop the growth of head and neck cancer by blocking blood flow to the tumor. It is not yet known whether combination chemotherapy is more effective when given with or without bevacizumab in treating patients with head and neck squamous cell carcinoma.
This description comes directly from the study's public registry record.
Talk to the study team
No contact information is available for this study as per the public registry record.
Always discuss trial participation with your own doctor first.
Locations (780)
| Providence Hospital | Mobile, Alabama, United States | — |
| University of South Alabama Mitchell Cancer Institute | Mobile, Alabama, United States | — |
| Fairbanks Memorial Hospital | Fairbanks, Alaska, United States | — |
| Mercy Hospital Fort Smith | Fort Smith, Arkansas, United States | — |
| NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro | Jonesboro, Arkansas, United States | — |
| John L McClellan Memorial Veterans Hospital | Little Rock, Arkansas, United States | — |
| University of Arkansas for Medical Sciences | Little Rock, Arkansas, United States | — |
| Kaiser Permanente-Anaheim | Anaheim, California, United States | — |
| Kaiser Permanente-Baldwin Park | Baldwin Park, California, United States | — |
| Kaiser Permanente-Bellflower | Bellflower, California, United States | — |
| Alta Bates Summit Medical Center-Herrick Campus | Berkeley, California, United States | — |
| Mills-Peninsula Medical Center | Burlingame, California, United States | — |
+ 768 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT00588770