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Hormone Therapy With or Without Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Negative Breast Cancer (The TAILORx Trial)
Condition: Breast Adenocarcinoma · Hormone Receptor Positive · Stage IA Breast Cancer AJCC v7 · Sponsor: National Cancer Institute (NCI)
About this study
This randomized phase III trial studies the best individual therapy for women who have node-negative, estrogen-receptor positive breast cancer by using a special test (Oncotype DX), and whether hormone therapy alone or hormone therapy together with combination chemotherapy is better for women who have an Oncotype DX recurrence score of 11-25. Estrogen can cause the growth of breast cancer cells. Hormone therapy may fight breast cancer by blocking the use of estrogen by the tumor cells or by lowering the amount of estrogen the body makes. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving hormone therapy together with more than one chemotherapy drug (combination chemotherapy) has been shown to reduce the chance of breast cancer recurrence, but the benefit of adding chemotherapy to hormone therapy for women with node-negative, estrogen-receptor positive breast cancer is small. New tests may provide information about which patients are more likely to benefit from chemotherapy.
This description comes directly from the study's public registry record.
Talk to the study team
No contact information is available for this study as per the public registry record.
Always discuss trial participation with your own doctor first.
Locations (1222)
| Northeast Alabama Regional Medical Center | Anniston, Alabama, United States | — |
| University of Alabama at Birmingham Cancer Center | Birmingham, Alabama, United States | — |
| Mobile Infirmary Medical Center | Mobile, Alabama, United States | — |
| Providence Hospital | Mobile, Alabama, United States | — |
| University of South Alabama Mitchell Cancer Institute | Mobile, Alabama, United States | — |
| Alaska Regional Hospital | Anchorage, Alaska, United States | — |
| Providence Alaska Medical Center | Anchorage, Alaska, United States | — |
| Fairbanks Memorial Hospital | Fairbanks, Alaska, United States | — |
| Banner Thunderbird Medical Center | Glendale, Arizona, United States | — |
| Banner Desert Medical Center | Mesa, Arizona, United States | — |
| Banner Baywood Medical Center | Mesa, Arizona, United States | — |
| Banner-University Medical Center Phoenix | Phoenix, Arizona, United States | — |
+ 1210 more locations — full list on the registry record.
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