Condition: Glioblastoma · Sponsor: Patrick Morris
This prospective study aims to characterize blood brain barrier (BBB) disruption in patients with newly diagnosed glioblastoma multiforme undergoing surgical resection. The study integrates advanced MRI, circulating BBB biomarkers, neurocognitive assessment, and molecular analysis of tumor tissue to investigate relationships between BBB integrity, tumor biology, and neurological function. Participants will undergo serial assessments before surgery, after surgery, and following radiotherapy. Tumor tissue collected during standard-of-care resection will undergo immunohistochemical and transcriptional
This description comes directly from the study's public registry record.
Professor Donncha O'Brien, MB, BCh, BAO, MCh, FRCSI (SN) · 018093000 · cancerdirectorate@beaumont.ie
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| Beaumont RCSI Cancer Centre | Beaumont, Ireland | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07731555