Condition: MCI · Mild Cognitive Impairment (MCI) · Mild Cognitive Impairment · Sponsor: Fondazione Don Carlo Gnocchi ETS
Cognitive impairment is common among older adults hospitalized for non-neurological conditions but often goes unrecognized, particularly in rehabilitation settings where clinical attention is mainly focused on physical recovery. The COGinREHAB study is a multicenter, prospective, longitudinal interventional study conducted at three rehabilitation centers of the Fondazione Don Carlo Gnocchi in Italy (Florence and Milan). The study will enroll 384 patients aged 45 years or older who are hospitalized for at least 7-10 days in cardiac, pulmonary, or orthopedic intensive rehabilitation units, or in intermediate care units, for conditions unrelated to the nervous system. At admission, all participants undergo a clinical and cognitive screening visit. Patients whose screening results suggest possible cognitive impairment then undergo a more extensive neuropsychological evaluation. In those with confirmed cognitive impairment, additional blood tests are performed to measure biomarkers of neurodegeneration (GFAP, neurofilament light chain, and phosphorylated tau-217), together with APOE genotyping and a non-contrast brain CT scan. In a subset of these patients, resting-state EEG, auditory event-related potentials, actigraphy, and overnight polysomnography are also performed. Patients with confirmed cognitive impairment are invited to a follow-up visit 12 months later to assess whether their cognitive profiles and biological markers have changed. The main purpose of the study is to …
This description comes directly from the study's public registry record.
Cristina Polito · +390557393653 · crpolito@dongnocchi.it
Clinical Trial Unit · +390557393653 · ctu@DONGNOCCHI.IT
Always discuss trial participation with your own doctor first.
| IRCCS Fondazione Don Gnocchi ETS | Florence, FI, Italy | Recruiting |
| IRCCS Fondazione Don Carlo Gnocchi ETS, Santa Maria Nascente | Milan, Michigan, Italy | Recruiting |
| Fondazione Don Carlo Gnocchi ETS, Istituto Palazzolo | Milan, Michigan, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07731334