Condition: Acute Respiratory Distress Syndrome (ARDS) · Sponsor: Southeast University, China
Acute respiratory distress syndrome (ARDS) poses a major threat to human health. Despite extracorporeal membrane oxygenation (ECMO) support, mortality among patients with ARDS remains high due to severe complications and suboptimal mechanical ventilation strategies. Elucidating the mechanisms underlying ECMO-related complications and lung injury repair, and establishing a precision intervention pathway covering the entire course of ECMO management, are urgent unmet needs for improving outcomes in ARDS patients and addressing major public health challenges. This project focuses on five key scientific questions: 1. How can moderate-to-severe ARDS be classified into distinct clinical-immune phenotypes, and what are the optimal therapeutic targets for each phenotype? 2. What are the molecular mechanisms underlying severe complications in ARDS patients receiving ECMO support? 3. Which key immune biomarkers are associated with clinical benefit from awake ECMO? 4. How should mechanical ventilation strategies be optimized in moderate-to-severe ARDS patients supported with ECMO? 5. How can a comprehensive, full-cycle ECMO management pathway be established for patients with moderate-to-severe ARDS? The project consists of five interrelated subprojects: Subproject 1. Construction of Clinical-Immune Phenotypes and Identification of Therapeutic Targets in Moderate-to-Severe ARDS Clinical phenotypes and longitudinal multidimensional biospecimens collected throughout the disease course …
This description comes directly from the study's public registry record.
yingzi Huang Yingzi，Huang · 18271428804 · yz_huang@126.com
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| Beijing Anzhen Hospital, Capital Medical University | Beijing, Beijing Municipality, China | Recruiting |
| Fujian Provincial Hospital | Fuzhou, Fujian, China | Recruiting |
| Zhongda Hospital, Southeast University | Nanjing, Jiangsu, China | Recruiting |
| Qilu Hospital of Shandong University | Jinan, Shandong, China | Recruiting |
| Sichuan Provincial People's Hospital | Chengdu, Sichuan, China | Recruiting |
| The Second Affiliated Hospital, Zhejiang University School of Medicine | Hangzhou, Zhejiang, China | Recruiting |
| The Second Hospital of Jilin University | Changchun, China | Not Yet Recruiting |
| The First People's Hospital of Chenzhou | Chenzhou, China | Recruiting |
| The Second Affiliated Hospital of Dalian Medical University | Dalian, China | Not Yet Recruiting |
| The First Affiliated Hospital of Guangzhou Medical University | Guangzhou, China | Recruiting |
| Hangzhou First People's Hospital, Westlake University School of Medicine | Hangzhou, China | Not Yet Recruiting |
| The First Affiliated Hospital of Harbin Medical University | Ha’erbin, China | Not Yet Recruiting |
+ 27 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07726940