Condition: Amyotrophic Lateral Sclerosis (ALS) · Autoantibody · Plasmapheresis · Sponsor: National Taiwan University Hospital
10-20% of patients with ALS have anti-NRIP autoantibody and the titer of anti-NRIP autoantibody is correlated with motor functional decline and mortality in ALS. The PALADIN2 clinical trial is a single arm study, which intends to enroll 20 ALS patients having anti-NRIP autoantibody in plasma. Patients will receive 3 courses of plasmapheresis per 3 months in order to maintain low concentration of anti-NRIP autoantibody in plasma. The study will follow up these patients for another 6 months after plasmapheresis. This project will potentially confirm the efficacy and safety of plasmapheresis for ALS patients having anti-NRIP autoantibody.
This description comes directly from the study's public registry record.
Li-Kai Tsai, MD, PhD · +886972651560 · milikai@ntuh.gov.tw
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| National Taiwan University Hospital | Taipei City, Taipei, Taiwan | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07726563