Condition: Helicobacter Pylori · Early Gastric Cancer · Sponsor: Chinese PLA General Hospital
This multicenter retrospective and prospective real-world observational study will evaluate the relationship of Helicobacter pylori (H. pylori) infection status, intragastric distribution, and pathological features with gastric cancer biological behavior and long-term prognosis in patients with early gastric cancer or related gastric neoplastic lesions undergoing endoscopic submucosal dissection (ESD). H. pylori infection is an important risk factor for gastric cancer. In clinical practice, H. pylori status can be assessed by several methods, including the 13C-urea breath test, serum H. pylori antibody testing, and pathological assessment of gastric tissue. These methods may not always provide the same result because they reflect different aspects of infection, including current active infection, previous exposure, prior eradication status, and local tissue-based detection. The study will include approximately 1500 participants from participating medical centers. About 1000 participants will be retrospectively identified from existing clinical, endoscopic, pathological, H. pylori testing, and follow-up records, and about 500 additional participants will be prospectively enrolled. The study will evaluate H. pylori infection status, prior eradication status, discordant testing patterns, tissue-based and intragastric H. pylori distribution, background mucosal changes, and pathological features of early gastric cancer or related gastric neoplastic lesions. These features will …
This description comes directly from the study's public registry record.
He Zhou, PhD · +86-13029650138 · zh505593673@163.com
Song Su, PhD · 13439710906@163.com
Always discuss trial participation with your own doctor first.
| The Eighth Medical Center of Chinese PLA General Hospital | Beijing, Beijing Municipality, China | Recruiting |
| First Medical Center of Chinese PLA General Hospital | Beijing, Beijing Municipality, China | Recruiting |
| Department of Gastroenterology, Rocket Force Characteristic Medical Center | Beijing, Beijing Municipality, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07724496