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Study identifier: NCT07720284 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

An Open-label Study to Investigate the Efficacy and Safety of Dato-DXd + Rilvegostomig vs SoC in Adult Participants With High-risk MIUC

Condition: High-risk Muscle Invasive Urothelial Carcinoma  ·  Sponsor: AstraZeneca

PhasePhase 3
Planned participants915
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Purpose: to assess efficacy and safety of Dato-DXd + rilvegostomig as adjuvant therapy versus SoC in MIUC participants with high-risk residual disease after radical resection. Study details: Duration: \~78 months (6.5 years) from FSI to last subject visit Treatment length: up to \~12 months, depending on randomized arm Visit frequency: every 3 weeks in Arms 1 and 2; every 2-4 weeks per SoC in Arm 3

This description comes directly from the study's public registry record.

Talk to the study team

AstraZeneca Clinical Study Information Center  ·  1-877-240-9479  ·  information.center@astrazeneca.com

Always discuss trial participation with your own doctor first.

Locations (160)

Research SiteHot Springs, Arkansas, United StatesNot Yet Recruiting
Research SiteLittle Rock, Arkansas, United StatesNot Yet Recruiting
Research SiteLittle Rock, Arkansas, United StatesNot Yet Recruiting
Research SiteSan Francisco, California, United StatesNot Yet Recruiting
Research SiteChicago, Illinois, United StatesWithdrawn
Research SiteBoston, Massachusetts, United StatesNot Yet Recruiting
Research SiteKansas City, Missouri, United StatesNot Yet Recruiting
Research SiteLincoln, Nebraska, United StatesNot Yet Recruiting
Research SiteOmaha, Nebraska, United StatesNot Yet Recruiting
Research SiteAlbany, New York, United StatesNot Yet Recruiting
Research SiteNew York, New York, United StatesNot Yet Recruiting
Research SiteCleveland, Ohio, United StatesNot Yet Recruiting

+ 148 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07720284