Condition: Psychosis · Schizo Affective Disorder · SCHIZOPHRENIA 1 (Disorder) · Sponsor: Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
This study examines whether an early-detection program for psychosis can shorten the time patients remain untreated after the first appearance of psychotic symptoms, and whether such a reduction improves later functioning for people with first-episode schizophrenia. Psychosis involves symptoms such as hallucinations and delusions. When these symptoms are recognized and treatment begins, most patients improve. However, many individuals live with psychotic symptoms for months-or even longer-before receiving care. This period is known as the duration of untreated psychosis (DUP). A long DUP has repeatedly been linked to poorer long-term outcomes, but it is still unclear whether DUP itself causes worse outcomes or simply reflects different illness courses. In Denmark, Region Zealand has implemented a large-scale early-detection effort. This includes public awareness campaigns and a specialized team that identifies people with emerging psychosis and helps them start treatment quickly. The Capital Region of Denmark provides usual care without these additional initiatives. This situation makes it possible to compare two regional systems that differ in their approach to early detection but provide the same specialized treatment once patients enter care. The study follows a quasi-experimental design, recruiting adults (18+) who receive a first diagnosis of a schizophrenia-spectrum disorder within the OPUS early-intervention programs in the two regions. No interventions are assigned…
This description comes directly from the study's public registry record.
Nikolai Albert, MD, PhD · +45 29925014 · nikolai.albert@regionh.dk
Stephen F Austen, PhD · +45 23259577 · stfa@regionsjaelland.dk
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| Mental Health Centre Copenhagen | Copenhagen, Denmark, Denmark | Recruiting |
| Region Zealand Psychiatry East | Roskilde, Denmark, Denmark | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07716969