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Study identifier: NCT07705334 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic Solid Tumors

Condition: Advanced or Metastatic Solid Tumors · Triple Negative Breast Cancer (TNBC) · HR+ Breast Cancer  ·  Sponsor: SHY Therapeutics

PhasePhase 1
Planned participants30
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a Phase 1, first-in-human (FIH), open-label, multicenter study designed to evaluate the safety, tolerability, PK, and preliminary anti-tumor activity of SHY-ONC6 in participants with advanced or metastatic solid tumors who have progressed on or are intolerant to standard therapies. The study will consist of 2 parts: a dose escalation part (Phase 1a) and a dose expansion part (Phase 1b).

This description comes directly from the study's public registry record.

Talk to the study team

Medical Monitor  ·  619-985-2706  ·  shyonc6@shytherapeutics.com

Clinical Operations  ·  shyonc6@shytherapeutics.com

Always discuss trial participation with your own doctor first.

Locations (3)

SCRI at HCA HealthONEDenver, Colorado, United StatesNot Yet Recruiting
The University of Texas MD Anderson Cancer CenterHouston, Texas, United StatesNot Yet Recruiting
NEXT OncologySan Antonio, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07705334