Condition: Primary Open Angle Glaucoma and Cataracts · Sponsor: Nanfang Hospital, Southern Medical University
The goal of this clinical trial is to learn whether doing phacoemulsification combined with gonioscopy-assisted trabeculotomy as an initial treatment can reduce the burden of glaucoma eye drops in adults with primary open-angle glaucoma and cataract. It will also learn whether this early surgical strategy improves ocular surface health and vision-related quality of life. The main questions it aims to answer are: Does early combined surgery reduce the need for long-term glaucoma medications? Does early combined surgery improve ocular surface health compared with cataract surgery followed by guideline-based glaucoma eye drops? Does early combined surgery improve vision-related quality of life and anxiety compared with the medication-based treatment strategy? What medical problems or complications do participants have after treatment? Researchers will compare phacoemulsification combined with gonioscopy-assisted trabeculotomy to phacoemulsification followed by guideline-based topical eye pressure-lowering medications. Participants will: Undergo cataract surgery with or without gonioscopy-assisted trabeculotomy Attend follow-up visits for 24 months after treatment Have eye pressure, visual acuity, OCT, AS-OCT, visual field, ocular surface, and safety examinations at scheduled visits Complete quality-of-life and anxiety questionnaires at scheduled visits Provide tear samples at selected visits for biomarker testing where applicable
This description comes directly from the study's public registry record.
Hongyang Zhang, PhD · +86-20-62787325 · hy3005716@163.com
Yuqiao Zhang, PhD · yqzhang@link.cuhk.edu.hk
Always discuss trial participation with your own doctor first.
| People's Hospital of Ningxia Hui Autonomous Region | Ningxia, Ningxia, China | Not Yet Recruiting |
| Nanfang Hospital, Southern Medical University | Guangzhou, China | Recruiting |
| The Affiliated Hospital of Southwest Medical University | Luzhou, China | Not Yet Recruiting |
| The First Affiliated Hospital of Zhengzhou University | Zhengzhou, China | Not Yet Recruiting |
| Zhuhai Hospital of Guangdong Provincial Hospital of Chinese Medicine | Zhuhai, China | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT07700498