← Eichor
Study identifier: NCT07699939 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Perioperative HLX10 (Serplulimab) With S-1+Oxaliplatin (SOX) in Locally Advanced and PD-L1-Positive Gastric or Esophagogastric Junction Adenocarcinoma

Condition: Gastric Adenocarcinoma · Gastroesophageal Junction (GEJ) Adenocarcinoma  ·  Sponsor: National Cancer Center, Japan

PhasePhase 2
Planned participants136
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

To evaluate the clinical efficacy of perioperative treatment with S-1 + oxaliplatin (SOX)+ HLX10 compared with SOX as the control in patients with cT3-4N1-3M0 PD-L1-positive (CPS ≥ 5) locally advanced gastric adenocarcinoma or gastroesophageal junction adenocarcinoma, in a placebo-controlled, double-blind, randomized phase II investigator-initiated clinical study.

This description comes directly from the study's public registry record.

Talk to the study team

Ken Kato, M.D., Ph.D.  ·  +81-3-3542-2511  ·  NCCH2414_office@ml.res.ncc.go.jp

Always discuss trial participation with your own doctor first.

Locations (18)

Chiba Cancer CenterChiba, Chiba, JapanRecruiting
Kyushu Cancer CenterFukuoka, Fukuoka, JapanNot Yet Recruiting
Gifu University HospitalGifu, Gifu, JapanNot Yet Recruiting
Gunma University HospitalMaebashi, Gunma, JapanNot Yet Recruiting
Hiroshima University HospitalHiroshima, Hiroshima, JapanNot Yet Recruiting
St. Marianna University HospitalKawasaki, Kanagawa, JapanRecruiting
Kanagawa Prefectural Hospital Organization Kanagawa Cancer CenterYokohama, Kanagawa, JapanNot Yet Recruiting
Saitama Prefectural Cancer CenterIna, Kitaadachi-gun, JapanNot Yet Recruiting
Osaka International Cancer InstituteOsaka, Osaka, JapanNot Yet Recruiting
Osaka Medical and Pharmaceutical University HospitalTakatsuki, Osaka, JapanNot Yet Recruiting
Saitama Medical University International Medical CenterHidaka, Saitama, JapanNot Yet Recruiting
Shizuoka Cancer CenterNagaizumi-chō, Sunto-gun, JapanNot Yet Recruiting

+ 6 more locations — full list on the registry record.

Follow this study

Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.

We email about this public record only. Unsubscribe anytime with one click. Never medical advice.

Is this your study? This page was generated automatically from the public registry record. Sponsors can claim it — free — to add branding and verified contact routing. Claim this page →

This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.

Source record: clinicaltrials.gov/study/NCT07699939