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Study identifier: NCT07699185 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Neoadjuvant Cardonilizumab Combined With Neoadjuvant Chemoradiotherapy Can Resect Locally Advanced Esophageal Squamous Cell Carcinoma

Condition: Esophageal Squamous Cell Carcinoma  ·  Sponsor: Tongji Hospital

PhasePhase 2
Planned participants336
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

This is a multicenter, open-label, randomized, controlled clinical study to compare the efficacy and safety of cardonilizumab combined with neoadjuvant chemotherapy and surgery versus neoadjuvant chemoradiotherapy and surgery in locally advanced ESCC. Subjects were randomly divided into experimental group and control group, the experimental group received neoadjuvant immunotherapy concurrent chemotherapy regimen, the control group received neoadjuvant concurrent chemoradiotherapy regimen, and then received McKeown surgery. The primary outcome measures were complete pathological response (pCR), and the secondary outcome measures were major pathological response (MPR), EFS (event-free survival), OS (overall survival), overall response rate (ORR), decreased pathological stage, R0 resection rate, adverse events (AE), and perioperative complications

This description comes directly from the study's public registry record.

Talk to the study team

Ni Zhang  ·  13871288490  ·  zhangnidoc@vip.163.com

Always discuss trial participation with your own doctor first.

Locations (1)

Tongji hospitalWuhan, Hubei, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT07699185