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Study identifier: NCT07695233 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Pedunculopontine Nucleus Transcranial Ultrasound Stimulation as a Treatment of Freezing of Gait in Parkinson's Disease

Condition: Parkinson Disease · Freezing of Gait Symptoms in Parkinson Disease  ·  Sponsor: Robert Chen

PhaseNA
Planned participants50
Who can joinAll sexes, 18 Years to 90 Years
Healthy volunteersYes

About this study

This study is investigating the use of transcranial ultrasound stimulation (TUS) on the Pedunculopontine nucleus (PPN) in changing freezing of gait in people with Parkinson's disease. The PPN is noted to be involved in voluntary movements, locomotion, and muscle tone. This will be assessed by patient-reported outcomes and analyzing the gait. The study will also investigate the effects of the stimulation on the PPN and surrounding connectivity by using magnetic resonance imaging (MRI).

This description comes directly from the study's public registry record.

Talk to the study team

Julian Kwok  ·  416-603-5800  ·  julian.kwok@uhn.ca

Always discuss trial participation with your own doctor first.

Locations (1)

Toronto Western HospitalToronto, Ontario, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT07695233