Condition: Sarcopenia · Sponsor: I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Sarcopenia is an age-related condition characterized by progressive loss of skeletal muscle mass, muscle strength, and physical performance. It is associated with frailty, falls, disability, reduced independence, lower quality of life, and increased healthcare burden. Despite its clinical relevance, sarcopenia remains underdiagnosed, partly because current diagnostic approaches may be difficult to implement broadly in clinical practice and may not fully capture early changes in muscle quality and neuromuscular function. The EXEDOS study aims to evaluate an integrated diagnostic and therapeutic strategy for the early detection and management of sarcopenia. The study will assess Quantitative Ultrasound with Radio-Frequency analysis (QUS-RF) as a non-invasive, accessible, and radiation-free tool to characterize muscle morphology, microstructure, and quality. QUS-RF-derived parameters will be compared with established assessments, including body composition, muscle strength, physical performance, and imaging-based measures, to determine their feasibility, reliability, diagnostic accuracy, and responsiveness to change. The study also includes a 48-week randomized, parallel-group, open-label superiority trial designed to evaluate the effects of a digitally delivered home-based exercise intervention in older adults with sarcopenia or at risk of sarcopenia. Eligible participants will be randomized to either an experimental group receiving a structured home-based exercise program or…
This description comes directly from the study's public registry record.
Matteo Bonato, Ph.D. · +390283502246 · matteo.bonato@unimi.it
Stefano Borghi, Ph.D. · stefano.borghi@grupposandonato.it
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| IRCCS Ospedale Galeazzi-Sant'Ambrogio | Milan, Mi, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07692308