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Study identifier: NCT07691840 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Intrathecal Therapy Versus Standard Care for Severe Cancer Pain

Condition: Intrathecal Drug Delivery · Refractory Cancer Pain · Conventional Medical Management  ·  Sponsor: Universitair Ziekenhuis Brussel

PhaseNA
Planned participants72
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Approximately 66% of patients with advanced cancer experience pain, which is often inadequately controlled and associated with a decline in health-related quality of life (HRQoL). Conventional pharmacologic management, ranging from simple analgesics to strong opioids, is frequently limited by insufficient efficacy and systemic side effects. Intrathecal drug delivery (IDD) offers targeted, continuous medication infusion directly into the intrathecal space, allowing lower systemic doses and potentially reducing side effects while maintaining effective analgesia. The CAREGIVER study is a randomized, controlled trial designed to evaluate whether patients with severe refractory cancer pain receiving IDD experience a difference in HRQoL compared to those receiving conventional medical management (CMM) with oral pain medications.

This description comes directly from the study's public registry record.

Talk to the study team

Maarten Moens, MD PhD MBA  ·  +3224775514  ·  stimulusresearchgroup@gmail.com

Lisa Goudman, MSC, PhD  ·  +32472412507  ·  lisa.goudman@vub.be

Always discuss trial participation with your own doctor first.

Locations (1)

UZ BrusselJette, BelgiumRecruiting

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Source record: clinicaltrials.gov/study/NCT07691840