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Study identifier: NCT07687966 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

CBP-0276 to Reduce Opioid Use in Adults Undergoing Major Orthopedic Surgery

Condition: Hip or Knee Replacement  ·  Sponsor: Clarent Biopharma, Inc.

PhasePhase 2
Planned participants80
Who can joinAll sexes, 40 Years to 75 Years
Healthy volunteersNo

About this study

Randomized, double-blind, clinical study to evaluate the safety and efficacy of CBP-0276 at doses of 600 mg/day in reducing opioid use in pain management in adult patients undergoing major orthopedic surgery. Subjects will be allocated in 2 groups. One group will receive oxycodone (standard of care) + CBP-0276 at a dose of 600 mg, orally once daily for 28 days. A second group will receive oxycodone (standard of care) + placebo for CBP-0276, orally once daily for 28 days

This description comes directly from the study's public registry record.

Talk to the study team

Pedro Gutiérrez Castrellón, MD, PhD  ·  +525554198746  ·  pedro.gutierrez@elemental.org.mx

Diana M Andrade Platas, MD  ·  +525535209755  ·  diana.andrade@elemental.org.mx

Always discuss trial participation with your own doctor first.

Locations (1)

Innovacion y Desarrollo de Estrategias en SaludMexico City, MexicoRecruiting

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Source record: clinicaltrials.gov/study/NCT07687966