Condition: Acute Myocardial Infarction (AMI) · Sponsor: Ankara University
Acute myocardial infarction (AMI) initiates a complex myocardial repair process involving inflammation, fibroblast activation, and extracellular matrix remodeling, which may ultimately lead to adverse left ventricular remodeling and impaired cardiac function. Fibroblast activation protein (FAP)-targeted positron emission tomography (PET) enables noninvasive visualization of activated fibroblasts and may provide an early imaging biomarker of myocardial remodeling. This prospective single-center observational study aims to evaluate myocardial fibroblast activation using Ga-68 FAPI PET/MR performed approximately 10 ± 2 days after AMI and to investigate its association with subsequent left ventricular remodeling. Serial cardiac magnetic resonance (CMR) examinations will be performed at 3 and 6 months to assess changes in ventricular function and remodeling. The study will investigate whether early myocardial FAPI uptake is associated with subsequent structural and functional changes detected by CMR and evaluate the potential role of Ga-68 FAPI PET/MR as an imaging biomarker for post-infarction remodeling.
This description comes directly from the study's public registry record.
Elgin Ozkan, Prof.Dr. · +90 312 595 6445 · ozkanelgin@yahoo.com
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| Ankara University Faculty of Medicine, Department of Nuclear Medicine | Ankara, Turkey (Türkiye) | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07684924