Condition: Male Infertility · Male Subfertility · Sponsor: Fakih IVF Fertility Center
With declining fertility rates Worldwide, Assisted Reproductive Technology is seen as a viable solution for infertility, however, individual success rates following ART remain relatively low, rarely exceeding \~50%. The European Society for Human Reproduction and Embryology (ESHRE) indicates pregnancy rates per embryo transfer remain below 50%. Additionally, male infertility is regarded as a leading contributor to global infertility with approximately a third of cases attributed to genetic causes while half of the cases remain unexplained. In this observational study we investigate the correlation between phospholipase C Zeta (PLCζ ) measurements and semen parameters. PLCζ is a sperm-specific protein which is introduced into a mature egg (oocyte) following gamete fusion and upon introduction, PLCζ is believed to initiate a series of characteristic calcium ion oscillations which lead to oocyte activation and persist beyond the completion of meiosis. Mounting evidence implicates defects in PLCζ in cases of male factor infertility where intracytoplasmic sperm injection (ICSI; whereby a single sperm is injected into the oocyte) is unsuccessful. Furthermore, defects in PLCζ are also increasingly implicated in cases of male sub-fertility, which affects a much larger proportion of the global population. Numerous studies now indicate that PLCζ not only holds significant value as a therapeutic to rescue cases of ICSI failure, but also as a prognostic diagnostic test of male fertilit…
This description comes directly from the study's public registry record.
Dr. Lamiya Mohiyiddeen, MD, FRCOG · +971543676002 · lamiya.mohiyiddeen@fakihivf.com
Fatma Bathawab, PhD · +971585707393 · fatma.bathawab@fakihivf.com
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| Fakih IVF | Abu Dhabi, United Arab Emirates | Recruiting |
| Khalifa University | Abu Dhabi, United Arab Emirates | Active Not Recruiting |
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Source record: clinicaltrials.gov/study/NCT07684339