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Study identifier: NCT07678268 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Effectiveness and Safety of Darunavir/Cobicistat Plus Lamivudine Compared With Darunavir/Cobicistat Plus Tenofovir Alafenamide/Emtricitabine in Virologically Suppressed People Living With HIV at 24 and 48 Weeks of Follow-up

Condition: HIV Infection · Antiretroviral Therapy · Lentivirus Infections  ·  Sponsor: Instituto Mexicano del Seguro Social

PhasePhase 4
Planned participants78
Who can joinMale, 18 Years to no upper limit
Healthy volunteersNo

About this study

A single-center, open-label, randomized pilot clinical trial between March 2025 and March 2026 at the Hospital de Infectología "La Raza" National Medical Center in Mexico City. Eligible participants were adult males (≥18 years) with HIV-1 infection who had maintained virological suppression (HIV-1 RNA \<50 copies/mL) for 48 weeks on either DRV/c + 3TC or DRV/c + TDF/FTC prior to enrollment (TLALOC-1 trial), and had an estimated glomerular filtration rate (eGFR) by CKD-EPI ≥60 mL/min/1.73 m². The primary endpoints were virological efficacy and safety at 24 weeks.

This description comes directly from the study's public registry record.

Talk to the study team

José Antonio Mata Marín, Master  ·  +524428518215  ·  sandrarmzeg@gmail.com

Jóse Antonio Mata Marin, Master  ·  4428518215  ·  sandrarmzeg@gmail.com

Always discuss trial participation with your own doctor first.

Locations (1)

Hospital de Infectología "Dr Daniel Méndez Hernández" National Medical Center "La Raza", Instituto Mexicano del Seguro SocialMexico City, Mexico City, MexicoRecruiting

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Source record: clinicaltrials.gov/study/NCT07678268