Condition: Duchenne Muscular Dystrophy (DMD) · Cardiomyopathy · Becker Muscular Dystrophy · Sponsor: Vanderbilt University Medical Center
Dystrophin associated heart dysfunction is a leading cause of death in patients with Duchenne and Becker Muscular dystrophy (DMD/BMD) and Duchenne and Becker muscular dystrophy carriers (MDC); however, the evolution of heart dysfunction is not well-understood. The central objectives of this proposal are to elucidate this evolution of heart dysfunction and identify measures from cardiac MRI images that can predict death or significant heart disease in patients with DMD/BMD/MDC. This study will create a large clinical and cardiac MRI registry of dystrophin associated heart dysfunction, will utilize advanced image analysis techniques, including deep learning neural networks, to comprehensively evaluate every patient, and will create a risk toolkit accessible to clinicians around the world; this proposal has the potential to improve the quality of life in patients with dystrophin associated heart dysfunction by allowing for earlier and more intensive therapy in patients with severe disease and by identifying surrogate outcome measures for use in therapeutic trials.
This description comes directly from the study's public registry record.
Jonathan Soslow, MD, MSCI · 615-322-7447 · DMDMachineLearning@vumc.org
Always discuss trial participation with your own doctor first.
| UC Davis | Sacramento, California, United States | Recruiting |
| Children's National | Washington D.C., District of Columbia, United States | Recruiting |
| Lurie Children's | Chicago, Illinois, United States | Recruiting |
| Riley Children's Hospital | Indianapolis, Indiana, United States | Recruiting |
| Duke Children's Hospital | Durham, North Carolina, United States | Recruiting |
| Nationwide Children's | Columbus, Ohio, United States | Recruiting |
| Vanderbilt University Medical Center | Nashville, Tennessee, United States | Recruiting |
| Children's Hospital of Richmond at VCU | Richmond, Virginia, United States | Recruiting |
| Seattle Children's | Seattle, Washington, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07674758