Condition: Oxidative Stress in Neonates · Near Infrared Spectroscopy · Fetal Hemoglobin · Sponsor: Medical University of Graz
Reactive oxygen species (ROS), which include peroxides, are generated in the human body as by-products of cellular metabolism. In small amounts, they fulfill important physiological functions. However, when produced in excess, they can damage cells and tissues. Extremely low gestation age neonates (ELGANs) are particularly vulnerable to such harmful effects because their antioxidant defense systems are immature, and they are exposed to increased ROS levels due to the oxygen therapy required after birth. Fetal hemoglobin (HbF), the primary oxygen carrier in the blood of newborns, plays a crucial role in this context. Compared with adult hemoglobin (HbA), it has a higher oxygen affinity and a more pronounced pseudoperoxidase activity, which helps protect organs during early development from peroxides. In addition to oxygen administration, blood transfusions can also contribute to increased ROS formation. Due to the immature hematopoietic system and the diagnostic blood sampling required, ELGANs frequently receive transfusions with adult red blood cell (A-RBC) concentrates. These lead to a rapid shift from HbF to HbA, further promoting the generation of ROS. Measuring ROS in blood is particularly challenging because these molecules are extremely short-lived. Consequently, reference values for newborns are lacking. Therefore, the investigators aim to establish reference ranges for one ROS, the peroxide in both term and preterm healty neonates from birth event onward and to ass…
This description comes directly from the study's public registry record.
Ena Suppan, MD · +4331638581477; +436766459070 · ena.suppan@medunigraz.at
Gerhard Cvirn, Associate Professor, PhD · +43-316-385-72122 · gerhard.cvirn@medunigraz.at
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| Divison of Neonatology, Department of Pediatrics, Medical University of Graz | Graz, Styria, Austria | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07672275