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Study identifier: NCT07669220 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Multicenter, Randomized Controlled Phase II Study of Short-Course Radiotherapy Followed by Sequential PD-1 Inhibitor and FOLFOX Chemotherapy Versus Long-Course Chemoradiotherapy for High-Risk Locally Advanced pMMR/MSS Lower Rectal Adenocarcinoma (STAR Trial)

Condition: Rectal Adenocarcinoma · High-risk Locally Advanced · Short-course Radiotherapy (SCRT)  ·  Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University

PhasePhase 2
Planned participants76
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

This study adopts a prospective randomized controlled design to evaluate the efficacy and safety of short-course radiotherapy followed by sequential PD-1 inhibitor and FOLFOX chemotherapy versus conventional regimens in high-risk locally advanced pMMR/MSS lower rectal adenocarcinoma, aiming to provide high-level evidence supporting a novel treatment paradigm.

This description comes directly from the study's public registry record.

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Locations (1)

The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhou, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT07669220